Hyatt Regency Bethesda

7:00 - 8:00 AM Light Breakfast
8:00 - 8:15 AM Welcome and Introductions
Stephen I. Katz, M.D., Ph.D., Director, NIAMS
Richard Hodes, M.D., Director, NIA
Julie Wolf-Rodda, MA, Director of Partnership Development — Foundation for NIH 
Gayle Lester, Ph.D., Project Officer for the OAI, NIAMS


Session I — Where is the OAI Now?

Moderators: Belinda Seto, Ph.D., Deputy Director, NIBIB
Norman Braveman, Ph.D., Assistant to the Director, NIDCR
8:15 - 8:45 AM OAI — Where Did We Start and Where Are We Now?
Michael Nevitt, Ph.D., University of California San Francisco, PI OAI Coordinating Center
8:45 - 9:15 AM How Can Investigators Use the OAI Resource?
Charles McCulloch, Ph.D., University of California San Francisco, Biostatistics
9:15 - 9:45 AM Role of Biomarker Initiatives in FDA Critical Path Program
Janet Woodcock, M.D., Director, Center for Drug Evaluation and Research, FDA
9:45 - 10:00 AM Pharmaceutical Industry Perspective on Biomarker Initiatives
Monica Luchi, M.D., Novartis


10:00 - 10:15 AM Break

Session II — View From Within the OAI

Moderators: Lisa Begg, Ph.D., Director of Research Programs, ORWH
Partap Khalsa, D.C., Ph.D, Program Director, NCCAM


OAI Clinical Centers

10:15 - 10:30 AM Where is OA Pain Located in the Knee?
Methods of Assessment and Patterns

C. Kent Kwoh, M.D., PI University of Pittsburgh OAI Clinical Center
10:30 - 10:45 AM Effect of Weight Change on Knee Pain in OAI Participants
Marc Hochberg, M.D., MPH, PI University of Maryland OAI Clinical Center
10:45 - 11:00 AM Knee Pain, Physical Activity and Function in OAI Participants
Rebecca Jackson, M.D., PI Ohio State University OAI Clinical Center


OAI Ancillary Studies

11:00 - 11:15 AM Thrust and Meniscal Lesions in Knee OA in the OAI
Leena Sharma, M.D., Northwestern University, Ancillary Study PI
11:15 - 11:30 AM Relation of Knee Alignment and Other Risk Factors to Knee OA
David Felson, M.D., MPH, Boston University, Ancillary Study PI
11:30 - 11:45 AM The Role of Bone in OA Progression
Timothy McAlindon, M.D., MPH, Tufts University, Ancillary Study PI


Session III — View From Outside the OAI

Moderators: Bernadette Tyree, Ph.D., Program Director, NIAMS
Tamara Harris, M.D., M.S., Senior Investigator, NIA
11:45 - 12:00 PM Change in Cartilage Morphometry Over One Year: 
Studies in the Progression Cohort of the OAI

David Hunter, MBBS, Ph.D., MSc, New England Baptist Hospital
12:00 - 12:15 PM Strong Association of Bone Marrow Lesions and Effusion with Pain in OA
Grace Lo, M.D., Tufts University
12:15 - 12:30 PM Instrument Development for the OAI
Sharmila Majumdar, Ph.D., University of California San Francisco
12:30 - 12:45 PM A Consortium for Analysis of MR Images from the OAI
Felix Eckstein, M.D., Paracelsus University, Salzburg, Germany


12:45 - 1:30 PM Lunch on Concourse Terrace (Lobby Level)

1:30 - 2:00 PM State of OA Clinical Research — Value of Longitudinal Cohorts
Stefan Lohmander, M.D., Ph.D., Lund University, Lund, Sweden


Session IV — View of the Future

Moderators: Chhanda Dutta, Ph.D., Branch Chief, NIA
Joan McGowan, Ph.D., Musculoskeletal Diseases Division Director, NIAMS
2:00 - 2:45 PM Proposal For and Discussion of Extension of Follow Up of OAI Cohort
Michael Nevitt, Ph.D., and Charles McCulloch, Ph.D.
2:45 - 3:20 PM Q & A Session with OAI Steering Committee — Evaluation Team
3:20 - 4:00 PM Q & A Session with OAI Steering Committee & Speakers — Audience
4:00-4:30 PM Wrap up and Summary
Stephen I. Katz, M.D., Ph.D., Director, NIAMS
Richard Hodes, M.D., Director, NIA
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